GCAT| Data Access

Context

GCAT'Genomes For Life, Prospective Population-Cohort Study of the Genomes of Catalonia, is a biomedical project aimed at facilitating the prediction, prevention and personalised treatment of complex and chronic diseases such as diabetes, heart disease, respiratory diseases or cancer. The project started 10 years ago by obtaining biological samples and information on the state of health (medical, clinical, environmental and lifestyle data) of 20,000 volunteers' resident in Catalonia. GCAT monitors the vital process that leads from health to disease, including its progression and treatment. This initiative aims to comprehensively understand the complex interplay among genetics, lifestyle and environmental factors that influence the risk of developing the disease and impact its treatment. The connection of the electronic health records, through the PADRIS program, allows objective monitoring of the 20,000 volunteers in real time with their interaction with Catalonia's public health services.

GCAT research develops a transdisciplinary model for investigating and improving health and its wider determinants, while building a transversal scientific and technological resource to foster transdisciplinary approaches to health challenges. In this sense, the collaborations established with principal actors of region biomedical research ecosystem have been essential in the development of two fundamental aspects of the GCAT project: the creation of a map of genetic variation of the Catalan population, and the FAIRification of the data generated during the GCAT activity. It is important to highlight three critical phases in the implementation of the project: data generation, data availability and data access and translational application of the generated knowledge to clinicians, the research community, volunteers and the broader society.

HOW TO ACCESS THE SUMMARY STATISTICS:

           Please, to personalize the access to the data we suggest that you:

  1. Fill in this online form to gain access to GCAT GWAS summary statistics. 
  2. Follow the instructions on how to download summary statistics are sent to you by e-mail.
  3. Download the data. 

         

(1)"Multiomic integration analysis identifies atherogenic metabolites mediating between novel immune genes and cardiovascular risk"

(2)"Skin Phototype and Disease. A Comprehensive Genetic Approach to Pigmentary Traits Pleiotropy using PRS in the GCAT Cohort"

ACKNOWLEDGEMENTS:

Please, when using these results in publications, remember:

1. Give recognition to the GCAT study. You can use the following text: "This study makes use of the data generated by the GCAT-Genomes for Life. Cohort study of the Genomes of Catalonia, IGTP. The IGTP is part of the CERCA / Generalitat de Catalunya Program. The GCAT has has been financed by Acció de Dinamización de ISCIII-MINECO.and the Ministry of Health of the Generalitat de Catalunya (ADE 10/00026). Health Assessment, within the framework of the PADRIS Program. The authors of this study would like to thank to all the researchers of the GCAT project who have contributed to the generation of the GCAT data. A complete list of the researchers is available at www.genomesforlife.com/. We thank the Blood and Tissue Bank of Catalonia (BST) and all the GCAT volunteers who participated in the study."

2. Cite the core GCAT publication Obón-Santacana, Mireia et al. "GCAT'Genomes for life: a prospective cohort study of the genomes of Catalonia". BMJ open vol. 8.3 e018324. March 27, 2018, doi:10.1136/bmjopen-2017-018324

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